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Let's Reflect

We're not bringing you an episode this week. We're taking some time to think about the systems we take part in and how those perpetuate anti black racism and the effects of that on the work in this field. We'd like to bring you meaningful conversations around those systems and how we...

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arXiv Whitepapers

Transcriptome dynamics of CD4+ T cells during malaria maps gradual transit from effector to memory

The dynamics of CD4+ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4+ T cells. We applied single-cell RNA sequencing and computational modelling to track...

A deep learning approach to programmable RNA switches

Engineered RNA elements are programmable tools capable of detecting small molecules, proteins, and nucleic acids. Predicting the behavior of these synthetic biology components remains a challenge, a situation that could be addressed through enhanced pattern recognition from deep learning. Here, we...

Virtual Monoenergetic CT Imaging via Deep Learning

Conventional single-spectrum computed tomography (CT) reconstructs a spectrally integrated attenuation image and reveals tissues morphology without any information about the elemental composition of the tissues. Dual-energy CT (DECT) acquires two spectrally distinct datasets and reconstructs energy...